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Fine Chem Trading (UK) - Supplier PH7437

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Conjugated Estrogen

Country of Origin: China
Please send your enquiries to: sales@chemfinder.co.uk

Product Information

Conjugated Estrogen extracted from Pregnant Mare's Urine. Conjugated estrogen is a mixture of estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It contains estrone, equilin, and 17 a-dihydroequilin, together with smaller amounts of 17 a-estradiol, equilenin, and 17 a-dihydroequilenin as salts of their sulfate esters.

Premarin is a drug made up of conjugated estrogens obtained from the urine of pregnant mares is produced in many forms (pills, creams, injections, patches, vaginal rings) and is used to reduce the symptoms of menopause in women or women who have had a hysterectomy. It is also prescribed to nearly eliminate the risk of osteoporosis (the brittling of bones) and reduce the chance of heart disease in women over 50.

Conjugated Estrogen Specifications

Synonyms: Premarin, Conjugated equine estrogens
CAS: 12126-59-9
Manufacturing Capacity: over 1000kg per month

Test Items

Specification

Appearance

Light yellow powder

Free Steroids

0.65 max

Assay

Conj.17a-estrsdiol

2.5%-9.5%

Conj.17α-dihydroequilin

13.5%-19.5%

Conj.17β-dihydroequilin

0.5%-4.0%

Conj.estrone

52.5%-61.5%

Conj.equilin

22.5%-30.5%

Sum of Estrone & Equilin

79.5%-88.0%

Total Conjugated Estrogens

Conforms

 

 

Conj.17α-dihydroequilenin

3.25% max

Conj.17β-dihydroequilenin

2.75% max

Conj.equilenin

5.5% max

Conj.17β-estrsdiol

2.25% max

Conj.Δ8,9-dehydroestrone

6.25% max

PH

10% w/v aqueous suspension

8.5-9.5

Water(Titrimetric)

2.0% max

Organic Volatile imputities

<467> Method V

Microbial Limits Test

Staphylococcus aureus

Negative

Escherichia coli

Negative

Pseudomonas aeruginosa

Negative

Salmonella species

Negative

Total aerobic plate count

1000 max

Water

0.5% max


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